Reactome

Reactome - a curated knowledgebase of biological pathways

Apoptosis	Axon guidance	Biological oxidations	Botulinum neurotoxicity
Cell junction organization	Cell Cycle Checkpoints	Cell Cycle, Mitotic	Chromosome Maintenance
DNA Repair	DNA Replication	Diabetes pathways	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Gene Expression	Hemostasis	HIV Infection	Influenza Infection
Integration of energy metabolism	Integrin cell surface interactions	Lipid digestion, mobilization, and transport	Membrane Trafficking
Metabolism of amino acids and derivatives	Metabolism of carbohydrates	Metabolism of lipids and lipoproteins	Metabolism of nitric oxide
Metabolism of nucleotides	Metabolism of polyamines	Metabolism of porphyrins	Metabolism of proteins
Metabolism of RNA	Metabolism of vitamins and cofactors	Muscle contraction	mRNA Processing
Myogenesis	Pyruvate metabolism and Citric Acid (TCA) cycle	Regulation of beta-cell development	Regulatory RNA pathways
Signaling by BMP	Signaling by EGFR	Signaling by FGFR	Signaling by GPCR
Signaling by PDGF	Signaling in Immune system	Signaling by Insulin receptor	Signalling by NGF
Signaling by Notch	Opioid Signalling	Signaling by Rho GTPases	Signaling by TGF beta
Signaling by VEGF	Signaling by Wnt	Synaptic Transmission	Transcription
Transmembrane transport of small molecules

About Reactome		News and Notes
REACTOME is a free, online, open-source, curated pathway database encompassing many areas of human biology. Information is authored by expert biological researchers, maintained by the Reactome editorial staff and cross-referenced to a wide range of standard biological databases. These include NCBI Entrez Gene, Ensembl and UniProt databases, the UCSC and HapMap Genome Browsers, the KEGG Compound and ChEBI small molecule databases, PubMed, and GO. The curated human data are used to infer orthologous events in 20 non-human species including the laboratory mouse and rat, the nematode C. elegans, budding and fission yeasts, two plants, and E.coli. Tools for pathway analysis include Skypainter and Biomart. Pathway data can be exported in SBML and BioPAX formats. A description of Reactome has been published in Genome Biology and Nucleic Acids Research. Protein-protein interaction datasets, statistics and the editorial calendar are available. The Reactome team thanks users for their comments on the pathway analysis and pathway visualization tools. Click on contact to reach us or contribute to Reactome content, and on subscribe to receive Reactome announcements. Please take note of our disclaimer.		July 23, 2010 Version 3 of Fly Reactome Released Version 3 of the FlyReactome Knowledgebase has been released and is accessible at http://fly.reactome.org. New pathway topics include Circadian Clock pathway, Hippo/Warts pathway, and Planar Cell Polarity. June 18, 2010 Version 33 Released Version 33 includes the new topic Chromosome maintenance regrouping existing annotations for Telomere maintenance with new annotations under Nucleosome assembly (Deposition of New CENPA-containing Nucleosomes at the Centromere). Topics in this release that contain new or revised and updated events include: Axon Guidance (L1CAM interactions and Netrin-1 signaling), Synaptic Transmission (Activation of Nicotinic Actetylcholine receptors), Transmembrane transport of small molecules (SLC-mediated transmembrane transport), Metabolism of proteins (N-Glycan biosynthesis), Diabetes pathways (Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins and Unfolded Protein Response), Signaling in the immune system (IL-1 signaling), and Signaling by GPCR (Olfactory Signaling Pathway). G Dall'Olio and K Ray are our external authors in this release. G Almouzni-Pettinotti, JA Chao, E Cooper, HM Cooper, E Dunleavy, DR Foltz, P Gagneux, L He, PF Maness, E Pinteaux, RH Singer , F Urano, and L Vosshall, are our external reviewers. Protein homology data used to predict Inferred Events in Reactome is now obtained from Ensembl Compara. Cross-references to RSCB Protein Data Bank, Comparative Toxicogenomics Database, DockBlaster, BioGPS, and dbSNP have been added to the protein pages. Recent papers describe the Reactome Functional Interaction protein network and R spider network-based analysis of Reactome pathways. Reactome will be attending ISMB 2010 and SIG BioPathways. More...

About Reactome

News and Notes

REACTOME is a free, online, open-source, curated pathway database encompassing many areas of human biology. Information is authored by expert biological researchers, maintained by the Reactome editorial staff and cross-referenced to a wide range of standard biological databases.

These include NCBI Entrez Gene, Ensembl and UniProt databases, the UCSC and HapMap Genome Browsers, the KEGG Compound and ChEBI small molecule databases, PubMed, and GO. The curated human data are used to infer orthologous events in 20 non-human species including the laboratory mouse and rat, the nematode C. elegans, budding and fission yeasts, two plants, and E.coli. Tools for pathway analysis include Skypainter and Biomart.

Pathway data can be exported in SBML and BioPAX formats.

A description of Reactome has been published in Genome Biology and Nucleic Acids Research.
Protein-protein interaction datasets, statistics and the editorial calendar are available. The Reactome team thanks users for their comments on the pathway analysis and pathway visualization tools.

Click on contact to reach us or contribute to Reactome content, and on subscribe to receive Reactome announcements.

Please take note of our disclaimer.

July 23, 2010 Version 3 of Fly Reactome Released
Version 3 of the FlyReactome Knowledgebase has been released and is accessible at http://fly.reactome.org. New pathway topics include Circadian Clock pathway, Hippo/Warts pathway, and Planar Cell Polarity.
June 18, 2010 Version 33 Released
Version 33 includes the new topic Chromosome maintenance regrouping existing annotations for Telomere maintenance with new annotations under Nucleosome assembly (Deposition of New CENPA-containing Nucleosomes at the Centromere). Topics in this release that contain new or revised and updated events include: Axon Guidance (L1CAM interactions and Netrin-1 signaling), Synaptic Transmission (Activation of Nicotinic Actetylcholine receptors), Transmembrane transport of small molecules (SLC-mediated transmembrane transport), Metabolism of proteins (N-Glycan biosynthesis), Diabetes pathways (Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins and Unfolded Protein Response), Signaling in the immune system (IL-1 signaling), and Signaling by GPCR (Olfactory Signaling Pathway).
G Dall'Olio and K Ray are our external authors in this release. G Almouzni-Pettinotti, JA Chao, E Cooper, HM Cooper, E Dunleavy, DR Foltz, P Gagneux, L He, PF Maness, E Pinteaux, RH Singer , F Urano, and L Vosshall, are our external reviewers.
Protein homology data used to predict Inferred Events in Reactome is now obtained from Ensembl Compara. Cross-references to RSCB Protein Data Bank, Comparative Toxicogenomics Database, DockBlaster, BioGPS, and dbSNP have been added to the protein pages. Recent papers describe the Reactome Functional Interaction protein network and R spider network-based analysis of Reactome pathways. Reactome will be attending ISMB 2010 and SIG BioPathways.
More...